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Non-invasive continuous blood pressure monitoring: a review of current applications

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《医学前沿（英文）》 2013年 第7卷 第1期   页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring     Riva-Rocci technique     oscillometric     Pe?áz technique     arterial tonometry     pulse transit time    

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超声血流的无创伤检测和医学信号的特征提取

王威琪,汪源源,余建国,吴晓峰,刘斌,张羽,陈斯中,仪艳华,邵谦明

《中国工程科学》 2001年 第3卷 第2期   页码 52-64

摘要：

人体信号是随机性和背景噪声都很强的复杂信号。文章首先研究了利用超声Doppler技术定量检测血流速度的方法，然后将一些现代信息处理中的新理论、新方法引入医学超声的信息处理，为医学超声信息的特征提取提供了新的手段。这些理论包括：分形、数学形态学、数量化、小波变换、极点轨迹和血管传输线模型等。文章最后阐述了利用上述新方法作为技术核心而研制的三套应用系统；肺动脉血液动力学参数的无损估测系统、彩色编码的声谱系统和超声血流定量检测系统。

关键词： 超声血流     医学信号     无创伤检测     特征提取    

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肺动脉压无创伤估测系统及其应用价值研究

王威琪,陈树宝,汪源源,刘斌,张玉奇,余建国,孙锟,陈斯中

《中国工程科学》 2000年 第2卷 第1期   页码 41-46

摘要：

肺动脉压是临床诊断、生理研究的一项重要指标，常规采用有创伤的心导管术测量。文章提出了一种基于超声和心电的无创伤估测方法，研制了肺动脉压无创伤估测系统。文中报告了所用的关键技术要点，动物实验和临床试用。所用的关键技术是小波变换降噪；新型百分比法提取声谱包络；小波变换识别定位超声；心电信号特征点。经9条狗的动物实验和60例临床试用，与心导管术相关性在80%以上。

关键词： 肺动脉压     无创伤估测     小波变换     降噪     包络     特征点    

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Deep convolutional neural network for multi-level non-invasive tunnel lining assessment

《结构与土木工程前沿（英文）》 2022年 第16卷 第2期   页码 214-223 doi: 10.1007/s11709-021-0800-2

摘要： In recent years, great attention has focused on the development of automated procedures for infrastructures control. Many efforts have aimed at greater speed and reliability compared to traditional methods of assessing structural conditions. The paper proposes a multi-level strategy, designed and implemented on the basis of periodic structural monitoring oriented to a cost- and time-efficient tunnel control plan. Such strategy leverages the high capacity of convolutional neural networks to identify and classify potential critical situations. In a supervised learning framework, Ground Penetrating Radar (GPR) profiles and the revealed structural phenomena have been used as input and output to train and test such networks. Image-based analysis and integrative investigations involving video-endoscopy, core drilling, jacking and pull-out testing have been exploited to define the structural conditions linked to GPR profiles and to create the database. The degree of detail and accuracy achieved in identifying a structural condition is high. As a result, this strategy appears of value to infrastructure managers who need to reduce the amount and invasiveness of testing, and thus also to reduce the time and costs associated with inspections made by highly specialized technicians.

关键词： concrete structure     GPR     damage classification     convolutional neural network     transfer learning    

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The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

《医学前沿（英文）》 2007年 第1卷 第2期   页码 121-125 doi: 10.1007/s11684-007-0023-5

摘要： Since first described in 1982, intraductal papillary mucinous neoplasm (IPMN) has been the preferred term to describe the proliferation of the pancreatic ductal epithelium. It is totally different from pancreatic carcinoma in epi demiology, histology, pathology and prognosis. According to the site of involvement, IPMNs are classified into three categories, i.e. main duct type, branch duct type, and combined type. Most branch duct IPMNs are benign, whereas the other two types are often malignant. A large branch duct IPMN and marked dilation of the main pancreatic duct indicate the presence of adenoma at least. The additional existence of large mural nodules increases the possibility of malignancy in all types. The prognosis is more favorable after complete resection of benign and non-invasive malignant IPMNs. Malignant IPMNs that become more aggressive after parenchymal invasion necessitate adequate lymph node dissection. On the other hand, asymptomatic branch duct IPMNs without mural nodules can be observed without the need for resection for a considerable period of time. Our review addresses available data, current understanding, controversy, and future directions about IPMNs.

关键词： available     additional existence     necessitate     intraductal papillary     non-invasive    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

《医学前沿（英文）》 2008年 第2卷 第2期   页码 178-181 doi: 10.1007/s11684-008-0033-y

摘要： To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipid profiles and blood glucose level. By using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure. Taking into account eNOS Glu298Asp polymorphisms, the relationship of blood pressure with triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose level was analyzed. The distribution of eNOS Glu298Asp polymorphism had no significant difference between different blood pressure groups and gender groups, but there was a significant difference between different age groups, diastolic blood pressure groups or BMI groups ( < 0.05). Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism and serum lipid could synergistically modulate the blood pressure. eNOS Asp/Asp genotype could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L. eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.
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神经退行性疾病的光学疗法及其应用展望

魏勋斌,周非凡,陶乐婵,杨思华,顾波波

《中国工程科学》 2020年 第22卷 第3期   页码 108-116 doi: 10.15302/J-SSCAE-2020.03.017

摘要：

神经退行性疾病是由神经元结构或功能逐渐丧失导致认知及运动障碍的一类不可逆损伤性疾病，目前尚无安全有效的治疗方法。探索无创的物理治疗手段在神经退行性疾病中的应用潜力，对疾病缓解与有效控制具有重大的意义。光学疗法是利用光线与组织的相互作用，通过光化学或光物理反应治疗疾病和促进机体康复的方法，具有精准性和微创性的技术特点。其中，弱光治疗作为一种无创光疗类型，在促进伤口愈合、缓解疼痛、炎症消退、组织再生等方面已广泛应用于临床。临床研究也证实弱光治疗能够有效改善神经退行性疾病病患的病理症状，作为一种无创物理疗法，弱光治疗为神经退行性疾病的缓解和有效控制提供了非常具有前景的新方向。本文综述了弱光治疗在神经退行性疾病中的研究进展，并结合光电子技术的发展展望其应用前景，研究提出：需阐明弱光作用机理及量效关系，开发新型弱光治疗技术，完善临床验证体系及评价指标，尽快造福病患，服务社会。

关键词： 光学疗法，弱光治疗，无创疗法，神经退行性疾病    

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K+ and Na+ fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

《农业科学与工程前沿（英文）》 2014年 第1卷 第2期   页码 144-149 doi: 10.15302/J-FASE-2014016

摘要： Maintenance of ion homeostasis, particularly the regulation of K and Na uptake, is important for all plants to adapt to salinity. Observations on ionic response to salinity and net fluxes of K , Na in the root exhibited by plants during salt stress have highlighted the need for further investigation. The objectives of this study were to compare salt adaptation of two Chinese Iris ( Pall. var. (Fisch.) Koidz.) populations, and to improve understanding of adaptation to salinity exhibited by plants. Plants used in this study were grown from seeds collected in the Xinjiang Uygur Autonomous Region (Xj) and Beijing Municipality (Bj), China. Hydroponically-grown seedlings of the two populations were supplied with nutrient solutions containing 0.1 (control) and 140 mmol·L NaCl. After 12 days, plants were harvested for determination of relative growth rate and K , Na concentrations. Net fluxes of K , Na from the apex and along the root axis to 10.8 mm were measured using non-invasive micro-test technique. With 140 mmol·L NaCl treatment, shoots for population Xj had larger relative growth rate and higher K concentration than shoots for population Bj. However, the Na concentrations in both shoots and roots were lower for Xj than those for Bj. There was a lower net efflux of K found in population Xj than by Bj in the mature zone (approximately 2.4-10.8 mm from root tip). However, no difference in the efflux of Na between the populations was obtained. Population Xj of continued to grow normally under NaCl stress, and maintained a higher K /Na ratio in the shoots. These traits, which were associated with lower K leakage, help population Xj adapt to saline environments.

关键词： Iris lactea Pall. var. chinensis (Fisch.) Koidz     population     K+ and Na+     ion flux     non-invasive micro-test technique    

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Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric

Gurmanik KAUR,Ajat Shatru ARORA,Vijender Kumar JAIN

《信息与电子工程前沿（英文）》 2015年 第16卷 第6期   页码 474-485 doi: 10.1631/FITEE.1400295

摘要： Accurate blood pressure (BP) measurement is essential in epidemiological studies, screening programmes, and research studies as well as in clinical practice for the early detection and prevention of high BP-related risks such as coronary heart disease, stroke, and kidney failure. Posture of the participant plays a vital role in accurate measurement of BP. Guidelines on measurement of BP contain recommendations on the position of the back of the participants by advising that they should sit with supported back to avoid spuriously high readings. In this work, principal component analysis (PCA) is fused with forward stepwise regression (SWR), artificial neural network (ANN), adaptive neuro-fuzzy inference system (ANFIS), and the least squares support vector machine (LS-SVM) model for the prediction of BP reactivity to an unsupported back in normotensive and hypertensive participants. PCA is used to remove multi-collinearity among anthropometric predictor variables and to select a subset of components, termed ‘principal components’ (PCs), from the original dataset. The selected PCs are fed into the proposed models for modeling and testing. The evaluation of the performance of the constructed models, using appropriate statistical indices, shows clearly that a PCA-based LS-SVM (PCA-LS-SVM) model is a promising approach for the prediction of BP reactivity in comparison to others. This assessment demonstrates the importance and advantages posed by hybrid models for the prediction of variables in biomedical research studies.

关键词： Blood pressure (BP)     Principal component analysis (PCA)     Forward stepwise regression     Artificial neural network (ANN)     Adaptive neuro-fuzzy inference system (ANFIS)     Least squares support vector machine (LS-SVM)    

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Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder

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《医学前沿（英文）》 2014年 第8卷 第2期   页码 241-249 doi: 10.1007/s11684-014-0328-0

摘要：

Approximately 70% of newly diagnosed bladder tumors are non-muscle invasive bladder cancer (NMIBC). NMIBC accounts for approximately 80% of total bladder cancer cases. Bacillus Calmette-Guérin (BCG) instillation and maintenance is considered as the standard adjuvant treatment for superficial bladder cancer. A number of randomized studies have focused on the benefit of maintenance therapy following initial BCG induction. To provide further insights into the effect of intravesical instillation on recurrence in patients with NMIBC, we analyzed this relationship by conducting an updated detailed meta-analysis. Evidence suggested that adjuvant intravesical BCG with maintenance treatment is significantly effective for the prophylaxis of tumor recurrence in patients with NMIBC.

关键词： non-muscle invasive bladder cancer     bacillus Calmette-Guérin (BCG)     meta-analysis    

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Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

《医学前沿（英文）》 2008年 第2卷 第1期   页码 19-24 doi: 10.1007/s11684-008-0005-2

摘要： The aim of this study is to investigate the effects of RNA interference (RNAi) targeting angiotensin 1a receptor (AT1a) on blood pressure and cardiac hypertrophy of rats with renovascular hypertension. Two RNAi plasmids, pAT1a-shRNA1 and pAT1a-shRNA2 each carrying a U6 promoter and an AT1a-specific shRNA-coding template sequence corresponding to the sites 928–946, 978–996 of the mRNA transcript, and a control plasmid pCon carrying a nonspecific shRNA-coding sequence were constructed. Thirty Sprague – Dawley rats with renovascular hypertension (2-kidney 1-clip) were randomly divided into 5 equal groups: Control group (without any intervention), pAT1a-shRNA1, pAT1a-shRNA2, pCon groups (with injection of the corresponding plasmid 4 mg/kg respectively into the tail vein), and valsartan group (30 mg/kg·d by gavage). Three weeks after drug administration, pAT1a-shRNA1, pAT1a-shRNA2 and valsartan respectively resulted in decrease of the tail blood pressure by (15.1 ± 5.4), (16.4 ± 8.4) and (30.6 ± 18.2) mmHg. However, the tail blood pressure increased further by about 25 mmHg in both of pCon and control groups. The carotid artery pressures of pAT1a-shRNA1, pAT1a-shRNA2 and valsartan groups were all significantly lower than those of the control and pCon groups. The ratio of left ventricle weight to body weight (LV/BW) of the rats in pAT1a-shRNA1, pAT1a-shRNA2, and valsartan groups decreased significantly than in the control group ( < 0.01), similar to those of the normal SD rats( > 0.05). Histopathological examination showed that the myocardiocytes were significantly hypertrophic and the basal membrane of the aorta was significantly thickened in the control group and such changes were alleviated in the pAT1a-shRNA1, pAT1a-shRNA2 and valsartan groups. Compared with the control group, pAT1a-shRNA1 and pAT1a-shRNA2 groups had lowered expression of AT1 receptor (in the myocardium and the thoracic aorta (all < 0.01); however, there were no significant differences in expression levels of AT1 receptor in valsartan and the control groups ( > 0.05). We conclude that RNAi targeting AT1a receptor inhibits the development of renovascular hypertension and the accompanying cardiac hypertrophy. RNAi technology may become a new strategy of gene therapy for hypertension.

关键词： therapy     Sprague     administration     cardiac hypertrophy     valsartan    

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Application of the invasive weed optimization algorithm to economic dispatch problems

T. JAYABARATHI, Afshin YAZDANI, V. RAMESH

《能源前沿（英文）》 2012年 第6卷 第3期   页码 255-259 doi: 10.1007/s11708-012-0202-1

摘要： In this paper the invasive weed optimization algorithm has been applied to a variety of economic dispatch (ED) problems. The ED problem is concerned with minimizing the fuel cost by optimally loading the electrical generators which are committed to supply a given demand. Some involve prohibited operating zones, transmission losses and valve point loading. In general, they are non-linear non-convex optimization problems which cannot be directly solved by conventional methods. In this work the invasive weed algorithm, a meta-heuristic method inspired by the proliferation of weeds, has been applied to four numerical examples and has resulted in promising solutions compared to published results.

关键词： economic dispatch (ED)     invasive weed optimization     non-convexity     prohibited operating zones (POZ)     valve point loading     meta-heuristic    

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REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARSOF MONITORING

《农业科学与工程前沿（英文）》 2023年 第10卷 第4期   页码 627-638 doi: 10.15302/J-FASE-2023516

摘要：

The agricultural and livestock activities surrounding the rivers flowing into the lakes have caused non-point source pollution, leading to excessive amounts of nutrient salts in downstream rivers. Introducing river water into constructed wetlands along river course has proven to be an effective solution for decreasing nitrogen (N) and phosphorus (P) loads. This paper reports 9 years of monitoring the Yong’an River and its surrounding constructed wetlands in the upper reaches of Erhai Lake, located in Yunnan Province, China. This study analyzed the main types of pollutants in the river, and evaluated the removal efficiency of pollutants by the constructed wetlands. The findings indicate that total nitrogen (TN) and nitrate nitrogen (NO3–-N) are the primary pollutants in the Yong’an River, which exhibit variation throughout the year corresponding to the alternating wet and dry seasons. Although constructed wetlands are effective in removing NO3–-N and P, their efficacy in removing ammonium nitrogen (NH4+-N) and organic pollutants is limited. This limitation can be attributed to the lack of timely disposal of aquatic plant residues. This research contributes to the understanding of the potential issues that may arise during the extended use of constructed wetlands and provides solutions to address them.

关键词： inflowing rivers     surface-flow constructed wetland     nutrients     long-term monitoring    

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一种非侵入式的基于功耗的可编程逻辑控制器异常检测方案 Article

Yu-jun XIAO, Wen-yuan XU, Zhen-hua JIA, Zhuo-ran MA, Dong-lian QI

《信息与电子工程前沿（英文）》 2017年 第18卷 第4期   页码 519-534 doi: 10.1631/FITEE.1601540

摘要： 工业控制系统广泛应用于关键基础设施的建设中，关系到国计民生，因此，攻击者越来越多地将其作为攻击目标，并造成严重的破坏。可编程逻辑控制器（Programmable logic controller, PLC）作为工业控制系统中的核心组件，能够直接控制现场设备，一旦PLC中运行了恶意程序，则可能直接造成重大财产损失甚至是人员伤亡。近些年来，针对PLC的攻击事件显著增加，这表明PLC存在很大的脆弱性，同时也提醒人们保护PLC安全的重要性。不幸的是，传统的入侵检测系统和杀毒软件并不能很好地保护PLC的安全，因此，针对PLC的有效的安全防护方案有待被研究。基于上述背景，本文提出了一种非侵入式的基于功耗的PLC异常检测方案。该方案通过分析PLC运行时的功耗变化来检测PLC中是否运行异常程序，分为功耗信息获取与功耗分析两部分。采集功耗信息是通过在PLC的供电线上串入一个电阻实现的，当PLC运行时，测量电阻两端的电压即可获取CPU的功耗信息。为了更好的分析功耗信息，本文首先从原始功耗数据中提取有效的特征值组合，然后利用正常样本来训练一个基于长短记忆（long short-term memory, LSTM）单元的神经网络模型，利用该模型对后续正常样本进行预测，通过比较测量到的功耗信息与预测的功耗信息，可以确定当前PLC中运行的程序是否为正常程序。该方案的优点是无需对原工控系统的封装部分进行软硬件的修改，且无需负样本即可实现对未知攻击的检测。我们在实验室测试平台上对该方法进行了评估，实验表明，对于原程序，只需改动0.63%即可达到99.83%的准确率。

关键词： 工业控制系统；可编程逻辑控制器；边信道；异常检测；基于长短记忆单元的神经网络模型    

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Performance monitoring of non-gaussian chemical processes with modes-switching using globality-locality

Xin Peng, Yang Tang, Wenli Du, Feng Qian

《化学科学与工程前沿（英文）》 2017年 第11卷 第3期   页码 429-439 doi: 10.1007/s11705-017-1675-6

摘要： In this paper, we propose a novel performance monitoring and fault detection method, which is based on modified structure analysis and globality and locality preserving (MSAGL) projection, for non-Gaussian processes with multiple operation conditions. By using locality preserving projection to analyze the embedding geometrical manifold and extracting the non-Gaussian features by independent component analysis, MSAGL preserves both the global and local structures of the data simultaneously. Furthermore, the tradeoff parameter of MSAGL is tuned adaptively in order to find the projection direction optimal for revealing the hidden structural information. The validity and effectiveness of this approach are illustrated by applying the proposed technique to the Tennessee Eastman process simulation under multiple operation conditions. The results demonstrate the advantages of the proposed method over conventional eigendecomposition-based monitoring methods.

关键词： non-Gaussian processes     subspace projection     independent component analysis     locality preserving projection     finite mixture model    

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标题 作者 时间 类型 操作

Non-invasive continuous blood pressure monitoring: a review of current applications

null

期刊论文

超声血流的无创伤检测和医学信号的特征提取

王威琪,汪源源,余建国,吴晓峰,刘斌,张羽,陈斯中,仪艳华,邵谦明

期刊论文

肺动脉压无创伤估测系统及其应用价值研究

王威琪,陈树宝,汪源源,刘斌,张玉奇,余建国,孙锟,陈斯中

期刊论文

Deep convolutional neural network for multi-level non-invasive tunnel lining assessment

期刊论文

The clinicopathologic features of intraductal papillary mucinous neoplasms of the pancreas

QIN Xinyu, LIU Fenglin

期刊论文

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

期刊论文

神经退行性疾病的光学疗法及其应用展望

魏勋斌,周非凡,陶乐婵,杨思华,顾波波

期刊论文

K+ and Na+ fluxes in roots of two Chinese Iris populations

Pinfang LI,Biao ZHANG

期刊论文

Using hybrid models to predict blood pressure reactivity to unsupported back based on anthropometric

Gurmanik KAUR,Ajat Shatru ARORA,Vijender Kumar JAIN

期刊论文

Can intravesical bacillus Calmette-Guérin reduce recurrence in patients with non-muscle invasive bladder

null

期刊论文

Effects of RNA interference targeting angiotensin 1a receptor on blood pressure and cardiac hypertrophy

ZHANG Jingqun, SUN Honglei, MA Yexin, WANG Daowen

期刊论文

Application of the invasive weed optimization algorithm to economic dispatch problems

T. JAYABARATHI, Afshin YAZDANI, V. RAMESH

期刊论文

REDUCTION OF NON-POINT SOURCE POLLUTION IN THE YONG’AN RIVER BY CONSTRUCTED WETLAND BASED ON 9 YEARSOF MONITORING

期刊论文

一种非侵入式的基于功耗的可编程逻辑控制器异常检测方案

Yu-jun XIAO, Wen-yuan XU, Zhen-hua JIA, Zhuo-ran MA, Dong-lian QI

期刊论文

Performance monitoring of non-gaussian chemical processes with modes-switching using globality-locality

Xin Peng, Yang Tang, Wenli Du, Feng Qian

期刊论文